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70: 名無しさん 2022/04/10(日) 15:54:13.91
魔術80と99でどれくらい変わるの?
76: 名無しさん 2022/04/10(日) 15:55:48.74
>>70
800ダメージが900ダメージになるくらいじゃないかな
84: 名無しさん 2022/04/10(日) 15:58:05.97
>>76
結構変わるね
96: 名無しさん 2022/04/10(日) 16:00:40.04
>>84
どう考えても同じなんだよなぁ
解凍が手間って言ってるけど二刀なら全然手間じゃねーし
116: 名無しさん 2022/04/10(日) 16:02:24.89
>>96
片方炎武器にしたら凍結までの手間が倍になるじゃん
127: 名無しさん 2022/04/10(日) 16:04:32.64
>>116
それでも全然強い定期
137: 名無しさん 2022/04/10(日) 16:06:39.16
>>116
普通は裏に入れるだろw
144: 名無しさん 2022/04/10(日) 16:07:17.84
>>116
片手だけ裏に同じモーションの火属性武器を挟んで、凍結したらそっちだけ持ち変えて連撃、
攻撃終わりに元の凍結武器に戻す
十字キーひとつで済む
113: 名無しさん 2022/04/10(日) 16:02:02.59
>>92
>>84
ごめんそんなに効果ないかも
800ダメージが850ダメージくらいかもしれない...
92: 名無しさん 2022/04/10(日) 15:59:44.20
>>76
そんなに効果ないでしょ

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  4. Hector より:

    Best PCT Strategies: Optimizing Post-Cycle Recovery Medical Advocacy And Outreach

    # Best PCT Strategies: Optimizing Post-Cycle Recovery

    Post-Cycle Therapy (PCT) is a critical phase for individuals who have completed anabolic steroid
    cycles. Without proper recovery, users may experience hormone imbalances, muscle loss, and other adverse
    effects. This article explores effective PCT strategies to
    help optimize post-cycle recovery, ensuring health,
    hormonal balance, and preservation of muscle gains.

    ## Key Takeaways

    PCT is essential for restoring the body's natural hormone production after steroid use.
    It involves a combination of medications, supplements, and
    lifestyle adjustments. Properly executed PCT can prevent hormone imbalances, support liver health,
    and preserve muscle mass.

    Understanding PCT and Hormone Regulation

    Hormones play a vital role in human physiology, regulating metabolism, growth, and reproductive
    functions. The endocrine system, composed of glands like the
    hypothalamus, pituitary, and adrenal glands, produces hormones that regulate production and activity.

    During anabolic steroid use, the body's own hormone production is suppressed
    due to feedback mechanisms. This suppression necessitates Post-Cycle Therapy
    to restore natural hormone production.

    Role of PCT in Hormone Recovery

    PCT helps reverse the suppression caused by steroids, allowing the
    body to resume producing hormones on its own. Without PCT, users
    may experience prolonged suppression of testosterone and other
    hormones, leading to adverse effects like fat gain,
    muscle loss, and sexual dysfunction.

    Effects of Steroids on Testosterone Levels

    Anabolic steroids suppress natural testosterone production by inhibiting
    the pituitary gland's ability to release gonadotropins, which stimulate hormone production in the
    testes. This suppression can lead to hypogonadism, a condition characterized by low testosterone levels and reduced libido.

    The Importance of Estrogen Regulation

    Estrogen is another critical hormone produced by the body.
    During steroid use, estrogen levels may rise due to aromatization, where steroids are converted into estrogen-like compounds in fat tissue.
    High estrogen levels can lead to side effects like gynecomastia, mood swings, and liver stress.

    Key Components of an Effective PCT

    An effective PCT regimen includes several components: duration, medications, supplements,
    diet, exercise, and monitoring. Each component plays a role in optimizing recovery and preventing side effects.

    Common PCT Medications and Supplements

    PCT often involves the use of medications like Clomiphene Citrate (to stimulate estrogen production), Arimidex
    (to reduce estrogen aromatization), and others such as Nolvadex, Propecia,
    and Testosterone Replacement Therapy (TRT). supplements like Ashwagandha, Vitamin D, and omega-3 fatty acids are also commonly used to support
    recovery.

    Natural Ingredients for Hormonal Balance

    Several natural ingredients are known for their ability to support
    hormonal balance and restore natural hormone
    production. Ashwagandha, a adaptogenic herb, has been shown to support the
    hypothalamic-pituitary-adrenal axis, potentially aiding in恢复.
    Vitamin D, often deficient in athletes, plays a role in hormone regulation and immune function.

    Dosage and Timing for Optimal Results

    The effectiveness of PCT depends on proper dosage and timing.
    Most PCT regimens last 4-6 weeks, with medications taken daily
    or weekly depending on the drug. supplements may be taken at specific intervals to enhance their effects.

    Managing Side Effects and Ensuring Health

    PCT can have its own side effects, such as nausea, fatigue, and mood changes.
    It's crucial to monitor these effects and
    address them promptly. Staying hydrated, maintaining
    a balanced diet, and avoiding alcohol can help mitigate
    these issues.

    Physical and Psychological Effects of PCT

    Recovery from steroid use extends beyond the physical
    to the psychological. Many users experience mood swings,
    anxiety, or depression during PCT. These effects are often linked to hormone imbalances and
    can be alleviated with proper monitoring and support.

    Supporting Liver Health During PCT

    The liver plays a key role in hormone metabolism, including the breakdown of anabolic steroids.
    Supporting liver health through diet, exercise, and reduced alcohol intake is essential during PCT to optimize
    recovery.

    Preserving Muscle Mass and Cycle Gains

    Maintaining muscle mass and the gains made during steroid cycles is a primary goal of PCT.

    This can be achieved through adequate protein intake,
    resistance training, and avoiding catabolic factors like excessive fat
    loss or stress.

    Frequently Asked Questions

    **What factors should be considered when selecting a
    post cycle therapy regimen?**
    Factors include duration, type of steroids used, individual
    health status, and the presence of concurrent medications.

    Consulting with a healthcare professional is recommended before starting
    PCT.

    **How do selective estrogen receptor modulators (SERMs) function in PCT?**
    SERMs like Clomiphene Citrate and Tamoxifen work by binding to estrogen receptors, blocking
    their activity or stimulating them depending on the specific SERM.
    This can help restore natural hormone production or reduce estrogen-related side effects.

    **What is the recommended timing for beginning PCT after a cycle of steroids?**
    PCT typically begins 4-6 weeks after the completion of a steroid cycle.

    The exact timing may vary based on the steroid used and individual recovery needs.

    **How can one effectively manage possible side effects during
    post cycle therapy?**
    Side effects like nausea or fatigue can be managed by adjusting medication schedules, staying hydrated, and maintaining a balanced diet.
    Monitoring emotional health is also important.

    **Is post cycle therapy necessary after every anabolic steroid cycle?**
    While not always mandatory, PCT is highly recommended after steroid use to prevent hormone imbalances and preserve health.

    Skipping PCT can lead to long-term health complications.

    **What are the consequences of skipping post cycle
    therapy after a steroid cycle?**
    Skipping PCT can result in persistent suppression of natural hormone
    production, muscle loss, fatigue, and other
    health issues. It may also increase the risk of
    developing metabolic syndrome or cardiovascular problems.

    Related Posts

    - Recent Posts

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  5. Donte より:

    This would join helicase activation to DDK release and due to this fact restrict DNA replication. Despite intensive analysis into DDK,
    many molecular mechanisms are nonetheless poorly understood.
    How DDK can dock on MCM2-7 and then reach its distant target sites in Mcm2, Mcm4 and Mcm6 still stay
    unknown. Right Here we report on the synthesis of dumbbell-like linear–dendritic
    copolymers primarily based on polyethylene glycols
    bearing aspartic dendrons with terminal amino and carboxylic groups.
    The ionic complexes of such oppositely charged copolymers reveal the flexibility to self-assemble in water and methanol and
    type gels in low polar solvents. Differential scanning
    calorimetry, polarizing optical and atomic drive microscopy, and X-ray diffraction methods point out a
    lamellar construction of PEG-copolymer complexes.
    Perform 7 reps of each train consecutively, then relaxation for 1 to 2 minutes.
    Repeat as much as 7 times, depending on how much dumbbell
    punishment you'll find a way to handle. Upper-body exercises are an excellent approach to strengthen your muscles, increase your
    bone health and even carry your mood. As you fatigue, you could
    have to actively concentrate on sustaining high quality reps.
    Merely flying via them with poor kind to "finish" the complicated is a
    simple approach to get injured, and the move won’t be nearly as
    effective. Again, that is why it’s important to maintain the "tougher"
    moves at the beginning of the complex. Complexes allow you to continue working out
    without rest regardless of this local fatigue by simply switching the physique part that you’re specializing in. The result is higher volume, a larger quantity of muscle being
    stimulated, and a higher metabolic demand.
    As such, the MD-(ADP-BeF3) construction might emulate changes that occur during
    the assembly of the replication fork and trace at a possible DNA unwinding
    mechanism. Dumbbells are nice for constructing a strong, muscular, well-developed chest as well as improving posture.
    They offer unique benefits that you simply can’t get with barbells or body weight exercises and are an excellent device to make the most
    of when focusing on chest fats loss. You are obviously
    not going to do all 15 dumbbell chest workout routines in a single
    workout, so here is how one can create a workout with the above workouts and how to program the rest shifting ahead.
    We're briefly explaining the chest anatomy because it's going to allow you to perceive how completely different movements
    and the positioning of your physique and arms have an effect on how your pec muscle tissue are activated.
    If you need to skip this and get proper to the exercises, maintain scrolling.
    If you're dead-set on training with nothing however a set of dumbbells, take a
    glance at these workouts as a leaping off point.

    Complexes are an attractive software for serving to you achieve
    these tantric-level sarogasms. Repetition and set modifications additionally enable productive suffering.
    Rep scheme models corresponding to ladders and pyramids let you create a
    less linear workout – one than may more intently resemble the chaotic topography
    of the event you’re making ready for. Frankly, real toughness is discovered when a person desires nothing greater than to quit halfway via their first 80 rep set, but
    pushes via the agony and finishes anyways – then does it once more three extra times.
    Some would possibly name that coronary heart or grit, however
    if you get right right down to it, toughness is basically just a
    deep trust in one’s conditioning.
    And unlike barbells, you sometimes don't have to go through the
    difficulty of including or subtracting plates when it's time to degree up or settle down. First of all, I did it as a
    outcome of complexes are, in my view, the cornerstone of any enjoyable time within the health club.
    Take Alwyn Cosgrove’s "Evil 8" for example, which you'll have the ability to
    see in it's full, nitty-gritty video element in my train advanced database here.

    It’s a 5 round painfest of deadlifts, Romanian deadlifts,
    bent over rows, energy cleans, front squats, push presses, back squats,
    and good mornings.
    Getups could additionally fall into the mobility section under, however when it comes to energy, they’re tough to
    beat. In Pavel Tsatsouline's e-book, Easy and Sinister, he mentions that old time Russian robust males wouldn’t prepare their apprentices till they may perform a getup with a one hundred lbs over their
    head. Incorporating high depth training like complexes lets you
    benefit from the metabolism-boosting benefits of extra post-exercise oxygen consumption (EPOC) for several
    hours after you put the weights down.
    The dumbbell incline fly is nice for building the upper-inner area of
    your chest. Focus on squeezing your chest to boost the
    dumbbell quite than using simply your arms. Get a deep stretch if your shoulder mobility allows for it,
    but there’s no need to go down too low to where the stress starts to be positioned on your shoulders quite than your chest muscle tissue.
    Harry Bullmore is a Health Writer for Fit&Well and its sister web site Coach, masking accessible residence workouts,
    energy coaching session, and yoga routines. He joined
    the team from Hearst, the place he reviewed products for Men's Well Being,
    Girls's Health, and Runner's World. He is passionate in regards to the bodily and psychological advantages of exercise, and splits his time between weightlifting, CrossFit, and
    gymnastics, which he does to construct power, increase his wellbeing, and have enjoyable.
    You in all probability deadlift a lot more than you
    bicep curl, so pairing them collectively in the identical complex might not make sense.

    You can use a complex as a "finisher" after your regular workout or, when you prefer, as a
    brief standalone coaching session between your regular
    exercises. The MD-(ATPγS) state III 3D-refined map suffered from conformational heterogeneity,
    significantly in regions corresponding to DDK. To alleviate this, we employed the use of multi-body refinement and adaptability analysis.
    These different structural states could replicate the coupling of DDK to Mcm4
    by way of completely different interplay motifs or the monitoring of the kinase alongside the Mcm4 tail so as to reach alternative sites for
    phosphorylation. Moreover, this binding mode
    involving multiple interaction websites might be essential for supporting
    the eventual launch of the kinase from the helicase advanced.

    Save $64 You solely want a set of dumbbells to do this exercise.
    If you do not already personal a pair, we like this low-cost set from Signature Fitness.
    Their hex shape means that they're sturdy enough for moves
    just like the renegade row and they won't roll away mid-workout.
    They're presently decreased, as a half of the Black Friday weights gross sales.
    Program them from probably the most demanding/taxing train to the least.
    If you might have Olympic actions in them, put them first, and try to keep the
    reps for them at 5 or much less. No matter which certainly
    one of these applies to you, complexes might help you conquer the difficulty.

    I love this program because you "get to" perform compound movements like squats and deadlifts 5 times/week.
    Workout Routines for the bigger muscle tissue, such as the ones in your shoulders
    and back, are often accomplished with heavier weights.

    The zero.5kg weights are suitable for ladies who have no expertise with energy coaching or haven’t exercised for
    a long time. If you don’t have a bench you'll find a way to perform
    flat presses and flys on the floor. You will be restricted in vary
    of movement on the eccentric part, but it'll still be efficient
    sufficient for training your chest. The upper chest, which is your clavicular head,
    is activated most when moving your arms up (shoulder flexion) or press at an upward
    angle. So, workout routines like incline dumbbell presses, incline flys, and seated or standing
    low to high flys will greatest target your higher chest.

    Phospho-proteomic analysis revealed substantial changes in the phosphorylation of Mcm4,
    Mcm2, Mcm6 and Dbf4 (Fig. 5c, d and Supplementary Desk 1).

    Overall, in the SCR mutant, we observed lowered phosphorylation of
    Mcm4 and enhanced phosphorylation of Dbf4, Mcm2 and Mcm6, though a few particular
    websites displayed the opposite behaviour. The impact was not the same for all sites, arguing that the SCR area modulates the number of DDK phosphorylation websites.
    Substrate interaction area I (SI) consists of the Dbf4 N-terminal part (aa111–220),
    which corresponds to the Dbf4 HBRCT area (aa105–220)
    and interacts with the Mcm2 N-terminal area
    (NTD) (aa179–285). Interplay I involves an invariant Dbf4 phenylalanine (F165)
    (Supplementary Fig. 5b) that binds right into a
    deep hydrophobic pocket on the floor of Mcm2 of hexamer 1 (Fig. 4a, b; Supplementary Fig. 6).
    In addition, there are a series of polar interactions
    that maintain the Dbf4 HBRCT domain on the Mcm2 surface (Fig. 4b–i; Supplementary Fig. 6).

    This pocket has a positive cost and will due to this fact symbolize
    a potential DNA binding site. Docking of double-stranded
    (ds) and fork DNA from the MCM2-7 DH45 and CMG57,
    respectively, indicate proximity to ds DNA (Supplementary Fig. 11b).
    This indicates that the positively charged surface could entice the ATPγS
    molecule, although it may even have a task in channelling ATP into the helicase motor.
    As we observed that the Dbf4 SCR area was cladding part of the cleft that lines the active
    aspect of Cdc7, we generated a mutant to handle the specific perform
    of this region. We replaced Dbf4 aa 509–538 with a 30 aa
    glycine/serine linker sequence. The mutant was
    competent for Dbf4 autophosphorylation (Fig. 5a) and MCM2-7 phosphorylation (Fig. 5b), although we
    noticed adjustments within the phospho-shift of Dbf4 and
    Mcm4.
    It not only engages the hamstrings and the higher
    body but additionally will increase explosive motion and fast-twitch muscle fibers, as
    you’re moving the dumbbells at a fast tempo from the
    ground to overhead. The additional weight and movement
    from the dumbbell press take it up a notch, participating the
    stabilizing muscle tissue of the core, shoulders, higher back, and triceps.
    Compound exercises are a sort of train that engages multiple
    muscle groups and joints simultaneously, permitting you to work extra muscles in less
    time. When we add dumbbells into the equation, this provides an added
    challenge to your exercise, but also the ability to further customise it based mostly in your energy and goals.
    You know the drill; perform 4-8 reps of each of the next exercises.
    As before, perform 4-8 reps of each of the following workout routines.

    Javorek designed the following set utilizing two dumbbells, which he considers among the
    many most effective coaching tools within the gym.

    The deep push up takes a daily push up to the next
    stage by allowing for a greater range of motion on the eccentric phase.
    Basically, you presumably can go deep, maximizing the stretching
    pressure in your chest. So, any movement that involves bringing the arm up,
    reaching or pressing forward, or bringing your arms throughout your body will activate the pectoralis main. The pec major is
    the larger of the 2 pec muscular tissues, making up most of the chest.
    The giant fan shaped-muscle has two heads,
    the sternocostal head, generally recognized as the lower chest, and the calvicular head,
    referred to as the upper chest. For fitness fanatics
    who like to construct muscle and contours, Custom Keychains may be designed based on their preferences and desires, helping them quickly determine
    their objects and keep away from confusion with other people's items.
    You May carry out each exercise for 30 seconds of work, then relaxation for 15 seconds.

    The dumbbell ‘complex’ beneath takes this a step further by stringing a collection of moves
    together seamlessly, all with the identical single piece of kit.
    A session with absolutely no reprieve that
    cranks up the trouble. You are clearly not going to do all
    of the above whole physique workout routines in a single exercise, so you will want
    to choose and select workouts that match nicely collectively.
    We love to include this type of complete physique dumbbell exercise at the end of our exercises
    as a burnout. It additionally makes for an excellent addition to an intense HIIT workout.
    The dumbbell renegade row to squat is a posh train that entails a number of workouts mixed into one.
    The step up alone is a great exercise for the quads, hamstrings and especially the
    glutes.
    For example, if a barbell advanced consists of squats, deadlift rows, overhead presses,
    and bent-over rows, perform all of the designated reps without leaving the barbell.
    The dumbbell snatch is an explosive exercise
    that may enhance whole body power and power with an emphasis in your shoulders, quads and again. Being that this
    is a "single arm" variation, it's also an anti-lateral
    movement, so your core goes to should battle to keep your physique from
    leaning to the working aspect.
    Do one train after the opposite with seconds in-between workouts.
    The plank hits your glutes, core, chest, triceps and shoulders in an isometric trend.
    The renegade row (which is a row from a plank position) works your biceps, back,
    and rear delts.
    This means you won’t have the flexibility to proceed a set previous the purpose your weak side can handle.
    It additionally ensures your type stays on point,
    as it won’t get all wacky with your stronger side powering most of the motion (like when somebody presses
    up a barbell with one facet greater than the other and does not even notice it).
    Finally, the energy and muscle imbalance will even out.

    Whether Or Not you understand it or not, throughout barbell presses,
    you have a stronger aspect that compensates for the weaker aspect by somewhat taking on the movement.

    "Dumbbells permit for unlimited vary of motion and stimulate your stabilizer muscles," says Javorek
    — two advantages that can’t be achieved on a
    machine. Since you by no means stop transferring during a complex, your
    coronary heart rate remains elevated. The legs have a little more juice when it
    comes to feats of muscular endurance, and the quadriceps have a tendency to respond quite properly to high volume and
    excessive rep work as far as hypertrophy goes.
    Let’s take advantage of this and exploit them for a excessive lactate
    burner. After performing the RDL with flat feet, step on to the dumbbells to mount your heels and emphasize the quads by keeping a
    vertical torso. Rack the weights on one finish on every shoulder (your
    elbows will keep up that way), or pres-hold them together in a goblet squat style (if
    you’re utilizing hexagonal dumbbells, this works surprisingly well).
    Most gyms that are ill-equipped or minimalistic
    have one thing in frequent – a dumbbell rack.

    This, in turn, then permits the next helicase activation complex, Sld3-Sld7, to
    interact with the phosphorylated N-terminal tails of Mcm4 and Mcm626.

    Subsequently, Sld3-Sld7 promotes the binding of Cdc45,
    whereas Sld2, Dpb11, GINS and Polymerase ε (Polε) turn out to be recruited upon S-phase particular cyclin-dependent kinase (CDK) activation27,28.

    These steps yield two Cdc45-MCM2-7-GINS (CMG) helicase complexes, which
    characterize the core of the replication fork29–31.
    Yes, dumbbell chest exercises can help address muscle imbalances.

    Because you're using a separate weight for every hand, stability is a greater
    factor. Not solely does this activate your major movers another way, however it additionally works the small
    stabilizer muscle tissue surrounding your joints, similar to your rotator cuff muscles,
    pec minor, serratus anterior, and rhomboids.
    The end end result might be stronger, extra resilient shoulder and scapula complexes.

    Exercises like flat presses will hit the middle and upper part of your sternocostal head, and decline
    presses and parallel dips will emphasize the lower area.

    Analysis means that dumbbell presses activate the pec main to a better diploma than barbells and smith machine
    bench presses because of each a larger vary of movement and demand for stability2.
    Chest and back workouts are nice as the chest and again are opposing muscle
    teams. With that, we wish to superset push workout routines with pull workouts.
    This is a good way to maintain your workouts efficient,
    effective, well-balanced, and excessive depth. The final on our greatest dumbbell chest train record is the decline fly.

    The clean is also an exercise that can be done with comparatively heavy dumbbells.

    Compound dumbbell workouts are categorised
    as exercises that stimulate all your major muscle groups, which
    leads to an elevated metabolic output (i.e., elevated fat burning)
    for several hours after your exercise. T-push-ups
    are a challenging, superior move that will construct robust stabilizer muscles within the core, and likewise work the whole higher
    body. It’s simply that it’s good to have an alternate, particularly
    one that’s as time-efficient and effective as energy training
    complexes. As the curl and press will in all probability be
    your weakest train, use that move to determine your coaching
    weight for the relaxation of the complicated. For instance, if you
    realize you can curl and press 20kg/45 lbs.
    All that mystical crap that everybody appears to think is optional like stretching and foam rolling
    is important. The older and extra lively I get,
    the extra I understand how necessary it is to cater to recovery.

    In fact, I’d argue that the effectiveness of your workout hinges more on the choices you make
    before and after you actually put the work in.
    This section collects any information citations,
    information availability statements, or supplementary supplies included in this article.
    Moreover, the Dbf4 SCR types a lasso around the most N-terminal resolved region of Mcm4
    and in this method could contribute in path of the specificity of Cdc7 to Mcm4 (Fig. 4b-III).
    A massive number of backbone-to-backbone contacts, within the lasso construction latching on Mcm4, could accommodate comparable binding modes when binding and phosphorylating alternative DDK substrates.

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