エルデンリングまとめ

【疑問】君主軍の直剣って強いんかね？？？

前日 人気記事ランキング

    データはありません

138: 名無しさん 2022/02/27(日) 00:28:00.16
君主軍の直剣って強いんかね
152: 名無しさん 2022/02/27(日) 00:29:07.46
>>138
火力爆上がりするでもなく振り遅くてロンソで良くねってなった
156: 名無しさん 2022/02/27(日) 00:29:49.89
>>152
かっこいいけど結局か
157: 名無しさん 2022/02/27(日) 00:29:52.02
>>152
振りロンソと同じじゃね
174: 名無しさん 2022/02/27(日) 00:31:01.99
>>157
遅いっしょ
同じだったらロンソ産廃じゃねえかw
186: 名無しさん 2022/02/27(日) 00:32:02.49
>>174
補正違うし
実際速度に違いを感じないのだが

引用元：https://pug.5ch.net/test/read.cgi/gamerpg/1645888256/

この件についてどう思う？

コメント一覧
  1. isototo より:
    2023年4月11日 8:19 AM

    Awesome! Its genuinely remarkable post, I have got much clear idea regarding from this post

    返信
  2. Fermin より:
    2025年3月24日 7:36 AM

    This sneaker from Core has a higher-than-average heel, which could be particularly
    useful for maintaining correct posture throughout again squats and other heavy lifts.

    Reviewers write that its stiff, stable sole is great for squatting, but it’s so sturdy that they wouldn’t wish to
    wear it for much else. The Core Weightlifting shoe is
    unquestionably a extra specialized decide, best if you’re working toward specific squatting objectives.

    Ultimately, power training shoes have the flat
    sole, but with added flexibility within the toe and midfoot that enables for extra motion and reactivity.

    Some even include further traction along the
    heel and lateral sides for rope climbs and other CrossFit activities.

    From there, we put the shoes via a wide selection of completely
    different actions the place comfort and assist were among the many most essential elements, and those
    guided us in making our last choices. Leave it
    to the consultants from one of the best outside brands on the earth to engineer one of the best path runners, too.
    Breathable and supportive, your ft will stay cool with out overheating.
    Every Thing you could probably need or need to hit the dust is here in one striking package deal,
    now it’s simply as much as you to put one foot
    in entrance of the other. Pope likes Nobull’s extremely sturdy footwear
    for the fitness center, and the brand’s Drive Knit model received
    a Sneaker Award last 12 months. The shoe's vast platform facilitates
    natural toe splay and provides reliable traction across numerous surfaces,
    further enhancing stability.
    If you may be a complicated lifter, then we are
    100% certain that you will love the Reebok Legacy Lifter III.
    This shoe is the most effective that we will provide to anyone who is already on prime of their weightlifting sport.
    In Addition To its immense sturdiness, we're
    in awe of the amount of stability that it was in a position to ship.

    A wood or TPU heel is crucial for improving your weightlifting performance.

    EVA foam is a superb option for a hybrid shoe or when you are on a tight price range.
    Lower heel top means much less ahead knee motion and
    could additionally be more durable for lifters with
    stiff ankles to hit depth. If ankle mobility is your only
    issue and also you need to make your favorite sneakers extra "weightlifting" friendly, you may give Versalifts
    a strive. The 0.6″ EVA heel interprets well into all kinds of various workouts within the
    gym. Nevertheless, because EVA is softer and compresses
    greater than TPU and wood, despite the name, high-level powerlifters
    won't like the shoe.
    We wore these on a 3-month Olympic lifting program and managed a 20-pound increase in his squat snatch and a 30-pound increase in his squat clean.
    Talking of squats, the exterior TPU heel reinforcement that rises up over
    the heel prevented any foot movement when dropping right into a squat and driving again up.
    That relies upon — if you’re already pissed off that most of the CrossFit sneakers on this list are
    round $150, this shoe’s not going to make you are feeling any
    better. Plus, they fit small, so you’ll want to go up half
    a measurement when purchasing.
    Paul has a master’s in Train Science and has taught CrossFit
    and power and conditioning classes to beginners and seasoned
    athletes for over five years. Through teaching and his personal training, Paul is able to
    put every shoe through the wringer. One of the cool features
    about this shoe is the built-in tongue, making the Minimus a great option for carrying with out socks.

    However, like several good CrossFit athlete, the Nike Metcon 9 can do nearly everything very,
    very well. These are one of the best bodybuilding sneakers that supply
    perfect stability and will forestall any sort of injuries from occurring, especially when conducting complex exercises.
    The shoes have good quality for the value,
    however as they begin going up in peak. Weighing only 14.eighty two ounces or 420 grams, this coach is indeed lots
    lighter than the typical which weighs 18.73 ounces or 531 grams.
    As A Result Of of the shoe’s lightness, we have been able to
    simply carry out workouts like box jumps and jumping ropes.

    We are simply not pleased with the truth that the upper materials just isn't essentially the most sturdy.

    We subjected the toebox to 12 seconds of drilling
    throughout our Dremel test, leading to an unlucky gap.

    I would argue that enhancing ankle mobility through deliberate coaching is better, but Veraslifts are the second-best thing.

    At the identical time, they are snug and designed as multipurpose footwear for
    all kinds of training. But for lifters with slim toes,
    it’s onerous to discover a better model than the Adipower
    three. Whereas plastic heels are more durable, the basic picket
    heel won't ever exit of fashion. Furthermore, wooden has been demonstrated
    to soak up a variety of the vitality and shock from weightlifting, making it somewhat gentler on the
    joints. With its exceptional quality and iconic picket heel, they outperform all other top brands and models.
    Wooden heels are difficult to search out in fashionable weightlifting, as many producers choose high-density plastic.

    I’ve been lacing up in weightlifting footwear for a while now and have
    experience with a quantity of the beneath picks. Notes surrounding lockdown and
    stability were closely examined in curating this roundup, as well as every sneaker’s traction atop various coaching platforms and overall
    comfort throughout the midfoot and toes. Plus, I
    checked out every silhouette’s heel-to-toe
    drop to see how aggressive an angle I’d be sitting at in my lifting stance.
    This measurement can significantly affect the place every profile
    matches best when it comes to weightlifting modality,
    so I’ve bulleted the statistic for each sneaker beneath.
    Good footwear stays comfortable while you’re strength training, but the best
    weightlifting sneakers can really improve your kind and
    hold you safe throughout your exercises.
    It has attained fan-favorite standing amongst devoted lifters for its big selection of motion and exceedingly
    stable base. I feel extremely stable, like I’m stepping on a platform,
    " one Nike reviewer wrote. However, like other stiff, lifted options in our roundup, it isn’t the most effective shoe for CrossFit or cardio exercises.
    They also make an excellent cheap option for people who desire a sturdy shoe that performs properly on and off the mat. This may have an affect on the muscles used during the squat (1, 2). These options might help forestall injuries related to weightlifting and promote good approach. As versatile because the shoe is, the fabric is actually quite sturdy and keeps your foot safe and secure whether you’re walking or understanding. While most testers rave about this shoe's versatility and efficiency, a number of note that the fabric does not maintain up in addition to different Alta sneakers.

    References:

    what are the long term effects of steroids (https://tyeala.com/testosterone-replacement-therapy-myths-and-facts)

    返信
  3. Kristin より:
    2025年3月24日 1:23 PM

    Its effects are influenced by complex mechanisms together with transcriptional
    and epigenetic regulation and modulation by extracellular binding
    proteins. Due to its actions in selling muscle atrophy and cachexia,
    myostatin has been investigated as a promising therapeutic target to counteract muscle mass loss in experimental models and patients
    affected by completely different muscle-wasting circumstances.
    Moreover, rising evidence indicates that myostatin,
    beyond to control skeletal muscle progress, may have a task in many physiologic and
    pathologic processes, corresponding to obesity, insulin resistance, cardiovascular
    and chronic kidney illness.
    Preclinical studies of ACE-083 demonstrated a dramatic enhance in muscle mass and energy in wild-type, Charcot-Marie-Tooth illness (CMT),
    and DMD disease mannequin mice [81]. In a phase 1 examine, ACE-083 injected in to the rectus femoris muscle of wholesome girls resulted in roughly
    a 14.5% enhance in local muscle mass however no change in muscle strength [82].
    Section 2 research in patients with FSHD or CMT also revealed important localized
    will increase in muscle mass however failed to show any enchancment in muscle function [83, 84].

    Notably, a study conducted by Iranian researchers five years in the past revealed promising outcomes.
    They discovered that administering a creatine
    supplement to energy athletes could successfully reduce myostatin production. Follidrone contains
    Ecklonia Cava (EC) which is a form of seaweed (we mentioned some other potential benefits from
    seaweeds in a previous article).
    The good news is that EGCG can be enzymatically transformed into
    its constituent molecules — epicatechin and gallic acid — that are readily absorbed, secure at numerous pH ranges,
    and seemingly much more helpful for longevity and athletic performance [7].
    With that in mind, let's take a look at the research behind epicatechin dietary supplements as ergogenic aids.
    If you've got ever taken a green tea leaf extract complement,
    odds are you are conversant in EGCG.
    Change in Wingate dash performance (mean ± SD) between groups following eight
    weeks of resistance training and supplementation. Epicatechin is a naturally occurring compound and has a positive influence on the
    physique. You can get epicatechin naturally from foods similar to dark cocoa or from
    extra concentrated supplements. When it involves cacao, you want to choose these utilizing cacao nibs or an extract for
    highest potency.
    The serum from the remaining separation tube was separated, labeled, and stored in micro centrifuge
    tubes at -80°C for later evaluation. Following completion of the examine, samples had been analyzed for lively testosterone,
    free testosterone, and cortisol with an enzyme immunoassay (EIA)
    assays utilizing Goat-Anti-rabbit IgG (GARG) coated microplates.

    Assays had been carried out utilizing a Jitterbug microplate shaker (Boekel Scientific-Philadelphia, PA)
    and a Tricontinent Multiwash Advantage microplate washer
    (Grass Valley, CA).
    Investigations have established that CKD is accompanied by mitochondrial impairment, a finding that is
    also seen in the aged [27]. Dynamin-related protein 1 (DRP-1) is an indicator of mitochondrial fission that sustains mitochondrial regular
    conditions. Microarray analysis of individuals with CKD,
    together with these present process hemodialysis,
    has indicated a compromised mitochondrial respiratory operate and consequent oxidative harm [28].
    When C2C12 cells reached 70% confluence, development medium
    was switched to myogenic differentiation medium supplemented with MIF1, MIF2,
    Ac-MIF1, or Ac-MIF2-NH2 for 3 days. Giemsa staining was
    performed and fusion indices have been decided as we beforehand described [52].
    C2C12 cells were grown in growth medium till 70% confluent,
    and then in myogenic differentiation medium (DMEM + 2%
    FBS + 1% P/S) supplemented with MIF1, MIF2, Ac-MIF1 and Ac-MIF2-NH2 for three
    days to promote myoblast differentiation. Scratch assays are often used to check cell
    migration parameters similar to velocity, persistence,
    and polarity [31].
    In vitro studies have proven that like FST, FLRG binds to activin and BMPs to inhibit their organic activities (Tsuchida et al., 2001).
    Furthermore, endogenous latent MSTN advanced largely circulates in association with propeptide and FLRG, which both act
    independently as unfavorable regulators of MSTN, most likely by stopping MSTN binding to its receptor
    (Thies et al., 2001). Reports counsel that FLRG potently inhibits MSTN activity in a concentration-dependent manner (Hill et al., 2002).
    In healthy older males, lower serum MSTN levels had been linked to lower SM mass,
    but not in women (Peng et al., 2018). It is also evident that
    serum MSTN does not differ in younger and sarcopenic aged men (Ratkevicius et al.,
    2011).
    These findings indicate that Ac-MIF1 and Ac-MIF2-NH2 could be useful therapeutic agents for the treatment of muscle-related ailments.
    Analysis, including randomized scientific trials with each
    scientific and sports populations, in addition to these with
    muscle-wasting situations like sarcopenia, provides combined results on myostatin inhibitors.
    These studies examine how food regimen dietary supplements, nutraceuticals, and train affect
    muscle tissues and blood myostatin. The findings present diversified
    results—some show decreases in myostatin levels, others show will increase, and a few discover no
    effect [1]. Dark chocolate extracts and comparable flavonol-containing extracts have been studied due
    to their skills to increase exercise performance.
    The particular flavanol, (–)-epicatechin, has been identified to extend nitric oxide production, improve
    mitochondrial biogenesis, enhance angiogenesis, decrease myostatin, enhance follistatin, and
    improve exercise efficiency in rodents.
    Following start, MSTN levels remain excessive, though not as elevated as during fetal improvement [30].
    MSTN-knockout animals, missing MSTN presence throughout prenatal or neonatal growth, exhibit a dramatic 2- to
    3-fold improve in muscle mass in comparison with wild-type animals [30].
    Homozygous mutant mice display roughly 30% extra body weight, with both
    bigger muscle tissue fibers in cross-sectional area (hypertrophy)
    and a higher in fiber quantity (hyperplasia). Moreover, MSTN-knockout animals demonstrate a higher proportion of type II fibers and a lowered
    variety of sort I fibers, together with decreased adipose tissue [30–32].
    Postnatal suppression of MSTN, achieved through conditional gene focusing on or the
    administration of MSTN inhibitors corresponding to its propeptide, antibody, or follistatin, induces significant but comparatively lesser will increase in skeletal
    muscle mass [33–35]. In contrast to MSTN-knockout fashions, muscle development from
    postnatal suppression of MSTN results solely from
    muscle hypertrophy, not hyperplasia, however nonetheless
    predominantly induces type II muscle fibers [36–38].

    To avoid eating darkish chocolate all day, many athletes and gym-goers choose to add a high quality epicatechin complement to their
    routine. If you go this route, consider enhancing your epicatechin intake by taking it with synergistic compounds corresponding to
    laxogenin, also identified as 5 alpha hydroxy laxogenin or
    5a-hydroxy laxogenin. If you're presently under the care of a doctor, pregnant, nursing, or
    dwelling with a well being situation, chat along with your doctor earlier than including this or any new supplement to your routine.

    As beforehand talked about, scientific studies of the soluble receptor ramatercept had been prematurely halted because of vital opposed effects,
    similar to nosebleeds, gum bleeding, telangiectasia, and erythema.
    These antagonistic events had been attributed to the
    unintended cross-inhibition of BMP9 and BMP10, important
    ligands involved in endothelial cell operate [12]. Future
    analysis and improvement efforts for MSTN inhibitors should prioritize specificity to mitigate off-target effects and enhance efficacy.
    Two current studies, performed in mouse fashions of cancer cachexia,
    have examined the results of myostatin inhibitors on bodily efficiency and muscle operate, building on earlier information that confirmed positive
    effects on muscle mass [30,31]. A myostatin antibody
    in the same mannequin was able to utterly abrogate the tumor-induced reduction in whole muscle drive in varied limb and diaphragm muscle tissue [33▪].

    The outcomes of those current studies are encouraging as the worth of myostatin inhibitors to most cancers sufferers
    exhibiting muscle losing is finally to affect functional performance via
    increased muscle perform.
    Useless to say, we're nonetheless quiet a means from understanding the intricacies of myostatin’s results on muscle hypertrophy.
    Muscle Fiber Quantity has long been recognized to be set on the
    early phases of pre and post-natal development. In a very real sense, you are born with
    a big issue of your muscular potential already dialled in. What’s particularly
    attention-grabbing is a core finding from scientific
    research involving "knock-out mice", where laboratory mice basically
    have their myostatin encoding gene switched off on the embryonic stage, and studies involving myostatin-inhibited adult mice.

    Whether or not these meals will have an result on myostatin inhibition is far less sure [31].

    Myostatin, also called development differentiation issue 8 (GDF8),
    is a remodeling growth factor-β (TGF-β) member of
    the family that potently inhibits skeletal muscle development
    [1]. The organic perform of myostatin became evident when mice homozygous for a deletion of myostatin gene exhibited a dramatic increase in skeletal muscle mass,
    with particular person muscle teams enlarging to approximately twice their normal size [1].
    In addition to its effect on skeletal muscle, myostatin has been demonstrated to play a big function in the regulation of bone metabolism by suppressing bone formation [6] and stimulating bone resorption [7].
    Indeed, myostatin null mice represent not only a doubling of muscle mass, but in addition enhanced bone mineral density (BMD) and bone regeneration [6,8].
    Duchenne muscular dystrophy (DMD) is an incurable disease that causes the lack of muscle
    tissue. Myostatin inhibition has been shown to extend muscle mass in canines and mice with
    DMD, suggesting that the potential of myostatin inhibitors should be
    investigated in human sufferers with DMD [7, 16].
    In the present examine, the impact of FOR supplementation had been in contrast with a macronutrient- and energy-matched placebo on indices of muscle
    dimension and energy during two weeks of single-leg immobilization in young, healthy men.
    Participants engaged in four cycling exercise classes per week for four weeks for a complete of sixteen periods (Table 2).

    Classes one and three of each week were accomplished independently on the University of South Alabama Recreation Heart using the prescribed depth and length and completion of every session was reported to study personnel.
    For the coaching classes in the recreation middle,
    individuals used the True Fitness CS 800 upright bicycle (True Health, St.
    Louis, MO).
    However, elevated levels of CRP lead to a reduction of the muscle
    cell size and lead to sarcopenia [132]. A multivariate biomarker strategy has been proposed as the optimal method for identifying losing
    illnesses, at the side of medical indications and manifestations.
    Skeletal muscle (SM) includes ~40% of body weight and is
    essentially the most dynamic organ, with an incredible ability to regenerate and repair
    after damage or trauma [1,2]. SM is answerable for the upkeep
    of postural assist, movement, thermogenesis, and blood glucose homeostasis [3,4].

    Additional research is required to see if sulfo-polysaccharides or cystoseira canariensis have any useful
    impact in humans in response to resistance coaching. Even if MSTN inhibition will increase
    muscle mass, it does not necessarily translate into
    improved useful energy in muscle wasting issues. While MSTN inhibition may stimulate muscle hypertrophy,
    its effectiveness in enhancing useful energy relies heavily on synergistic
    motor neuron activation and mechanical signaling induced
    by train. With Out adequate fusion of newly shaped myotubes with
    present muscle fibers, facilitated by neural enter,
    elevated muscle mass could not result in meaningful practical
    enhancements [108]. This limitation is very related in situations like DMD, the
    place neuromuscular junction vulnerability and lowered neural
    input contribute to impaired translation of neurological signals to skeletal muscle tissue [109].
    In distinction, mdx mice sometimes exhibit robust contractile function and maintain ambulation throughout their lifespan, which can elucidate
    why MSTN inhibition in these mice may find
    yourself in gains in both muscle mass and performance [110].

    Cell recoveries of MIF1- (22%) and MIF2-treated (22%) C2C12
    cells had been better than these of non-treated cells (Figure 3A).
    To investigate the results of MIF1 and MIF2 on myogenic differentiation, 70% confluent cells have been switched from growth medium
    to myogenic differentiation medium supplemented with MIF1 or MIF2 and incubated for three days.
    Myotube formation was elevated for MIF1- (4%) or MIF2- (12%)
    treated cells than for non-treated controls (Figure 3B).
    Myosin heavy-chain (MYH) mRNA expression was elevated and MSTN mRNA expression was decreased in MIF1-treated cells, whereas MSTN mRNA expression in MIF2-treated cells and
    non-treated controls had been comparable. MYOD, MYOG,
    myosin light-chain 2 (MYL2), and MYH proteins expression have been elevated in MIF1-
    or MIF2-treated cells, whereas MSTN protein expression elevated in MIF1-treated cells however not in MIF2-treated cells (Figure
    3C,D).
    They are regularly monitored by our inside peer-review
    process and if we see anyone making material science errors, we don't allow them to write for
    us again. SelfHacked has the strictest sourcing
    tips within the well being business and we almost exclusively link to medically peer-reviewed studies, normally on PubMed.
    We consider that probably the most correct information is discovered immediately within the scientific
    supply. Whereas options like SwissChems Myostatin 1 mg and PureRawz Myostatin deliver noticeable outcomes,
    they also carry risks. It’s vital to pair any supplementation with
    a strong health routine, balanced diet, and
    professional steering.
    The effect on skeletal muscle progress is doubtless considered one of the primary causes for the huge curiosity for epicatechin in recent years.
    One examine was in a place to determine that epicatechin from dark goodies inhibits myostatin. Low ranges of myostatin protein are
    fascinating as a end result of it leads to elevated capability to construct skeletal muscle mass.
    Phenolic compound resveratrol has anti-inflammatory and antioxidant properties that encourage the manufacturing of more antioxidant-related enzymes and activate transcription parts like NRF2 [189].

    As a end result, it could hinder the degradation of
    proteins, which is primarily caused by the angiotensin I and II routes,
    and phorbol ester via minimizing the expression of MAFbx,
    MuRF1, and NF-κB [190]. Furthermore, elevated NRF2 gene expression has been linked
    to the regulating of pro-inflammatory cytokines, primarily IL-6 and TNF.

    When administered to a mouse MD mannequin that exhibited excessive
    MSTN mRNA ranges, FS extract lowered these
    ranges in a dose-dependent manner (Kim et al., 2015). MSTN
    is translated as a precursor protein, which undergoes several
    proteolytic processing events that end result within the formation of lively, mature MSTN (Qian et al., 2015).

    Initially, the amino(N)-terminal signal sequence is
    removed by a signal peptidase to type Pro-MSTN, and dimerization follows as a end result of disulfide
    bond formation near carboxy(C)-termini. Subsequently, furin cleaves the dimer at its proteolytic processing web site
    RXXR web site. C-terminus cleavage leads to an N-terminal propeptide with
    an N-linked glycosyl group and a receptor-binding domain on the C-terminal.
    Latent MSTN advanced forms when the N-terminal
    propeptide binds the C-terminal area noncovalently through a crucial
    peptide sequence, which prevents MSTN from binding to its receptor.

    In the last stage, BMP-1/TLD cleaves the propeptide, which results in the release of mature MSTN.

    Male Kunming mice (6 weeks old) were purchased from the
    Center for Laboratory Animal Science and Technology, Jiangxi College of Traditional Chinese Language Medication (Jiangxi, China), and housed in group cages with a
    12 h light/dark cycle. The ambient temperature was maintained at 22 ± 2 C and the relative humidity
    was 40–60%. The eight MIF peptides selected by in silico
    research have been named MIF1, MIF2, Ac-MIF1, Ac-MIF2, MIF1-NH2, MIF2-NH2, Ac-MIF1-NH2, and Ac-MIF2-NH2, synthesized by
    Peptron (Daejeon, Korea), diluted with DMSO (Sigma Aldrich, St.
    Louis, MO, USA), and stored at −20 °C. The inhibitory efficacies of designed peptides against MSTN were predicted using an in silico binding approach.

    The inhibitory function played by MSTN in muscle improvement has made it an important therapeutic target
    for accelerating muscle mass. There are a number of
    ways of disrupting MSTN exercise starting from the usage of MSTN antibodies to pure compounds.
    Detailed data of those strategies and the utilization of in silico
    strategies ought to enhance knowledge of the structural traits
    of MSTN and its bindings with inhibitory proteins, derived inhibitors, and different pure compounds.

    Astragalus polysaccharide (APS; also known as
    Huang Qi) is a well known extract of Astragalus membranaceus (Fisch.) Bge (AMB) (Fu et al., 2013).
    Like other members of the pro-TGF-β superfamily, pro-MSTN is
    a homodimer comprised of two equivalent disulfide-linked subunits.
    Every chain consists of 109 amino acid residues containing a
    pro-domain (N-terminal) and a smaller development factor (GF) area (C-terminal).
    As present in different members of the TGF-β superfamily, the GF area of MSTN contains a cystine-knot motif and 4 antiparallel β-strands known as "fingers".
    The two similar GF domains of MSTN are related
    by their concave "palms", that are covalently linked to one another by disulfide bonds between C339 residues within the
    wrist area.
    EAA elevated muscle high quality (e.g., grip strength and maximal carrying load) with out corresponding
    changes in markers of mitochondrial biogenesis and neuromuscular junction stability.

    In conclusion, RT amplifies muscle mass and energy by way of
    modifications in muscle protein turnover in conjunction with changes in implicated signaling, whereas EAAs improve muscle quality by way of unknown mechanisms.
    Beige and brown adipocytes exist in WAT, contributing to the
    whole body’s energy expenditure. Totally Different
    stimuli (i.e. advanced hormonal interplay and numerous environmental factors) lead to WAT browning.
    Vitamin D may be saved in adipose tissue; thus its insufficiency might contribute to aberrant
    adipogenesis.

    References:

    buy steroids Com

    返信
コメントを残す

エルデンリングまとめの関連記事
おすすめの記事