エルデンリングまとめ

【疑問】1週目と2週目でマレニアの強さって結構変わる？

前日 人気記事ランキング

    データはありません

105: 名無しさん 2023/07/07(金) 13:36:02.33
1週目と2週目でマレニアの強さって結構変わりますか？
106: 名無しさん 2023/07/07(金) 13:49:58.44
瞬間移動から水鳥乱舞したりビームしたりメリナミニスカ履いたりするよ
107: 名無しさん 2023/07/07(金) 13:50:41.31
攻撃力が1.1倍程度上がる
108: 名無しさん 2023/07/07(金) 13:53:47.00
リーチの長い攻撃判定のあるバリアを纏いながらこっちに瞬間移して水鳥乱舞してくる
109: 名無しさん 2023/07/07(金) 13:58:48.10
リゲインじゃなくてリジェネを使ってくる
110: 名無しさん 2023/07/07(金) 13:59:42.79
単純に火力と体力上がるだけじゃないのか…
111: 名無しさん 2023/07/07(金) 14:08:31.95
攻撃力と体力とスタミナダメージが上がるだけだよ
112: 名無しさん 2023/07/07(金) 14:08:44.67
純粋無垢なお前のままでいてくれ

引用元：https://pug.5ch.net/test/read.cgi/gamerpg/1688546468/

この件についてどう思う？

コメント一覧
  1. Odessa より:
    2025年3月8日 11:48 PM

    Timeline For Testosterone Injections To Work + Stay In System

    Initial Injection: The testosterone is administered into the bloodstream,
    typically via subcutaneous injection. Effects begin within minutes to hours as the hormone starts to be absorbed.

    Absorption Peak: Approximately 24-72 hours after injection, peak levels of testosterone are reached
    in the bloodstream. This is when hormone levels are highest
    and most effective for physiological effects.

    Duration Of Effectiveness: Testosterone remains active in the body for about 4-6 weeks after the initial injection. Effects on things like libido, muscle growth,
    and bone density may diminish gradually during
    this period.

    Metabolism Peaks: The body metabolizes testosterone at a rate that causes half-life
    to be approximately 2-3 days. This means levels of active
    hormone are reduced by about half every 2-3 days, leading to the need for
    repeat injections.

    Elimination Half-Life: After several weeks, the remaining testosterone is metabolized and eliminated through urine,
    typically within 24-48 hours after the last effective dose.

    Total Active Period: With proper injection schedules (every 7-14 days), testosterone levels can be maintained at therapeutic levels for continuous effect
    over an extended period.

    **Time Range to Feel the Effects of Testosterone Injection**
    Testosterone injections are designed to quickly deliver testosterone into the body, initiating its effects.
    On average, individuals may notice changes within 24-72 hours after administration. However, absorption can vary based on factors like injection site and
    individual metabolism.

    ---

    **What Effects to Expect?**
    After testosterone injections, users typically experience increased libido,
    enhanced energy levels, and an overall sense of well-being.
    These effects are often felt within a few days to weeks.
    Some users may also notice improvements in muscle mass, bone density, and skin health over time.

    ---

    **When Will Testosterone Injection Start Working?**
    The injection works immediately upon administration, with testosterone entering the bloodstream
    quickly. By interfering with estrogen receptors and
    enhancing protein synthesis, it starts its effects rapidly.
    Most individuals report noticeable changes within a week, though
    full benefits may take several months.

    ---

    **Timeline of Testosterone Effects for Transgender Patients (FTM)**
    For transgender patients (FTM), testosterone injections are
    crucial for masculine traits like voice deepening and facial hair
    growth. While some effects like mood improvements may
    occur sooner, others like facial hair take longer,
    potentially several months. Each individual's response varies.

    ---

    **What About Other Forms?**
    Besides injections, other forms include patches, gels,
    and pellets. These alternatives absorb more slowly than injections, with effects taking days to weeks to
    manifest.

    ---

    **How Long Does Testosterone Stay in Your System?**
    Testosterone has a half-life of about 2-3 days, but can be
    detected up to several weeks post-injection due to its metabolites.
    Its duration depends on metabolism, liver function,
    and clearance rate.

    ---

    **You May Also Like**
    - **Testosterone Therapy Cost in the US**: Explore costs and payment options
    for testosterone therapy.
    - **How High Testosterone Makes You Tired: Can TRT Cause Fatigue?**:
    Understand potential fatigue linked to high testosterone levels.

    ---

    **Services**
    Our clinic offers comprehensive hormone replacement therapy, including
    consultations and personalized treatment plans. Contact us
    today for more information or an appointment.

    ---

    **Follow Us**
    Stay updated with our latest news and advancements in hormone therapy by following us on social media.

    ---

    **Legal**
    This article is for informational purposes only and does
    not constitute medical advice. Always consult a healthcare professional before starting any treatment.

    My website: injectable steroids list (https://suwontop.com/bbs/board.php?bo_table=free&wr_id=26350)

    返信
  2. Albertina より:
    2025年3月24日 9:45 AM

    It additionally focuses on findings in myostatin biology which will have implications for the event of antimyostatin therapies.
    Prospects are satisfied with the muscle energy and restoration benefits of the dietary complement.
    The product speeds up muscle restoration, making their workouts simpler and allowing them to take care of muscle mass.

    Two traits of senescent MPCs probably result in the common description of CKD as an inflammatory
    continual condition. Initially, senescent cells exhibit resistance to apoptosis, resulting
    of their continued existence in the senescent section.
    Secondly, they formulate an SASP characterized by sustained
    cytokine generation [57].
    Creatine compensated for the myostatin induced muscle fiber loss and even boosted the growth of the management
    fibers which hadn’t even been touched. Leucine and beta-hydroxymethylbutyrate (HMB) essentially reversed the 30% muscle fiber wastage that myostatin-treated myotubes exhibited.
    Together, they trigger a lot of the anabolic processes that lead to muscle hypertrophy.

    The follistatin-rich egg yolk extract called MYO-T12 that the product contained demonstrated somewhere around
    50% discount in myostatin levels. There has additionally been instances of human kids who've been born with abnormally low myostatin exercise that have highly developed muscle
    tissue.
    Understanding the function of myostatin has significant implications for creating therapies to treat muscle
    losing diseases and enhancing athletic efficiency. MSTN is known to work together
    with FST, GASP-1, GASP-2, decorin, FMOD, and FLRG, that are collectively known as MIPs.
    These proteins inhibit the formation of mature MSTN complicated and intrude with complex formation between MSTN
    and ACVRIIB. Designing quick peptides based on the make-up of MIPs provides a possible means of effective MSTN inhibitors, and some studies indicate
    that these inhibitory peptides have therapeutic potential for the treatment of a spread of muscular dystrophies (Tsuchida,
    2008). FS I-I (MSTN-specific inhibitor derived from FST) supplies an example of an FST-derived inhibitory peptide and elevated SM mass in mdx/FS I-I mice and reduced cell infiltration into muscle tissue
    (Tsuchida, 2008).
    Thus, Epi is the first compound ever noted, to favorably
    modulate each regulators of muscle progress and recommend will increase
    in power. From a biomedical perspective, myostatin inhibitors are a kind of drug that focus on myostatin,
    a protein involved in regulating muscle development and development.
    Myostatin inhibitors work by blocking the exercise of myostatin, which might result
    in elevated muscle mass and energy. These inhibitors have potential applications in treating muscle-wasting conditions, similar to muscular dystrophy, and
    can also be used to reinforce muscle growth in athletes
    and bodybuilders. By inhibiting myostatin, these
    medication can promote muscle hypertrophy and potentially enhance muscle perform.

    In phase 2 trials with boys affected by DMD, weekly doses of taldefgrobep
    alfa led to a modest 4.9% increase in lean physique mass
    index in the pooled therapy group compared to placebo, but
    finally discovered no change in motor perform [69].

    Further analysis focused toward DMD has been terminated,
    but a phase three research evaluating taldefgrobep alfa in SMA is at present underway.
    MSTN is primarily expressed in skeletal muscle but can also be expressed to a lesser extent
    in adipose tissue [15], coronary heart [16], and kidney [17].
    Like most different members of the TGF-β household, MSTN is secreted as an inactive precursor, comprised of an N-terminal sign peptide,
    N-terminal propeptide, and C-terminal progress issue (GF) domain [18].

    Lately, we carried out a VS-based evaluation on identified muscle-enhancing natural compounds
    for MSTN inhibitory activity and identified curcumin and gingerol as candidates (Baig et al., 2017).
    Undoubtedly, there are limitations of the VS approach that ought to be taken into
    consideration. The prevalence of stereochemical and valence errors
    in biochemical compound libraries could doubtlessly lead to inviable
    molecules (Williams et al., 2012; Santana et al., 2021).

    The specificity of the PCR was demonstrated with an absolute negative management response
    containing no cDNA template, and a single gene product was confirmed using DNA melt curve
    analysis. YK11 is a SARM that provide increased muscle growth,
    fast restoration, highlighted endurance, and distinctive energy.
    Bodybuilders who depend on muscle progress supplements have switched to YK11
    as a outcome of they imagine it is safer than different SARMs.
    Although YK11 has some anabolic steroid-like results,
    its efficacy is fairly restricted. It's vital to remember that YK11 takes time to
    work, and you must anticipate to take it for a minimal
    of 4-6 weeks before seeing any outcomes.
    Myostatin is produced by the muscle tissue of the heart, and damage to
    the guts causes it to be released into the bloodstream.

    As Soon As within the bloodstream, myostatin reaches the muscles and causes them to weaken over time.
    As a end result, patients with heart disease often also
    experience signs of muscle atrophy (muscle loss) [10].

    Bodily train, particularly weightlifting, can naturally lower myostatin activity.

    Research show that resistance coaching improves muscle fibers,
    reduces body fats, and stimulates skeletal muscle hypertrophy.

    Myostatin inhibitors block or lower myostatin activity
    and "unlock" your muscle-building potential. By suppressing myostatin expression or its signaling pathways, these inhibitors enable your body to create more
    muscle fibers and decrease muscle atrophy.

    Second, caution is required in the interpretation of findings exclusively drawn from circulating biomarkers when using "local" disuse models, corresponding to knee brace immobilization. Certainly, disuse effects are expected principally at a local muscle degree and
    results obtained from systemic biomarkers could also be
    affected by the relatively low muscle mass present process unloading/immobilization (one leg only).
    Due to the COVID-19 outbreak and the poor compliance with wearing a knee brace, we couldn't analyze the whole number of individuals deliberate to have a medium impact size of power (S1 File) and recognize that
    our findings are restricted to younger males. YK11
    is typically dosed at 10 to 15 milligrammes twice day,
    for a complete of as a lot as 30 milligrammes of SARMs every day.

    Inhibiting MSTN could have therapeutic purposes in promoting bone regeneration and healing in bone fractures, osteoporosis, rheumatoid arthritis, and
    osteoarthritis. In mice, administration of recombinant MSTN propeptide improved
    fracture therapeutic in a fibula osteotomy mannequin [150].
    Additionally, therapy of younger mice with ActRIIB-Fc led to elevated bone mass [151].

    Formulas of nutritional dietary supplements sometimes outpace the science behind their elements —
    epicatechin supplements are one other instance of that trend.
    Though it may possibly improve nitric oxide manufacturing and
    mitochondrial biogenesis, it's unclear if epicatechin confers significant muscle-building advantages.
    Inhibiting myostatin is an instance of disinhibition — when a molecule that
    usually inhibits a pathway is inhibited by one other molecule, an opposite impact results.

    In this case, the expression of myogenic components
    will increase when myostatin is inhibited. When myostatin binds to its receptor,
    ActRIIB, it activates a cellular pathway known as Smad that blocks
    genes from transcribing myogenic components.
    The product gives them a sense of nothing being heavy and
    stamina like they have not had, and they really feel they will go longer on the health club and do
    not have to attend too lengthy in between. They really
    feel nice every day, have better humor and power, and experience
    decreased urge for food, improved sleep high quality, and better restoration. C2C12 cells had been seeded into culture dishes, processed, and harvested based on the
    aforementioned protocol. Subsequently, LDH, SOD, and MDA activities
    in cells were assessed according to the manufacturer’s tips.

    Protein synthesis and degradation homeostasis are required for the upkeep of wholesome muscle mass and for sensitivity
    to bodily exercise, hormonal stability, harm, and nutritional standing [1].

    The IGF1-Akt-mTOR pathway is a constructive regulator of protein synthesis and is counterbalanced by the
    myostatin—Smad2/3 pathway, which acts as a unfavorable regulator [5].
    Imbalance within the myostatin—Smad2/3 pathway causes
    muscle atrophy, which, in the context of most cancers, known as cancer cachexia [6].

    Naturally, muscle loss happens from 35 years of age and ~30% loss happens between the ages
    of fifty and eighty [7]. SM loss is the primary attribute of getting older and illnesses similar to obesity, diabetes, and most cancers
    [8,9]. Interleukin-15 (IL-15) is highly expressed in SM and has anabolic effects on SM protein dynamics (Quinn et al., 2002).
    IL-15 mRNA expression is up-regulated throughout myoblast differentiation and its administration inhibits the white adipose tissue deposition in rodents (Quinn et al.,
    2005).
    These preclinical observations improve our comprehension of the function of miRNAs in CKD-triggered wasting of muscles, indicating that miRNAs may characterize viable potential targets for treating this condition. Fatigue is universally a devastating symptom among sufferers with CKD, affecting their quality of life which to some extent is
    as a end result of of excessive levels of lactate within the skeletal muscle tissue of those sufferers and is attributable to varied reasons.

    First, it’s already recognized that decreased arterial oxygen content
    in muscle tissue of CKD patients prevents the induction of
    a adequate compensatory improve in cardiac output.
    This insufficient response is generally attributed to the presence of underlying anemia,
    and each systolic and diastolic cardiac dysfunction, which
    are widespread findings in CKD [28]. On the other hand, diminished microvascular vasodilator response due
    to insulin resistance in diabetic patients with CKD can be able to inducing lactate overload.

    The decreased physical activity in CKD patients compared to wholesome controls is another contributing
    factor to the event of lactic acidosis and the resulting fatigue in these sufferers [28].

    Satellite cells (SCs), or cells with terminal differentiation possessing
    the capacity to renew muscle stem cells, make up the post-mitotic tissue known as skeletal muscle.

    Indeed, myostatin is taken into account a highly druggable goal and the current research demonstrates a potential novel nutritional strategy for its modulation that negates prior issues
    of poor ET/EA bioavailability. Polyphenolic plant extracts have
    demonstrated anti-inflammatory and anti-catabolic effects in vitro,
    nevertheless their significant translation into people remains elusive.
    Urolithin A (UA), a gut-derived metabolite of ellagitannins, has proven promise for enhancing muscle function and metabolic
    well being in rodent fashions. This research aimed to discover the influence of UA on insulin and anabolic sensitivity in human skeletal muscle cells.

    The manuscript must describe a technically sound piece of scientific analysis with information that supports the conclusions.

    Experiments should have been performed rigorously, with appropriate controls, replication, and pattern sizes.
    In whole, 24 members had been recruited, and 22 completed the protocol; 2 participants dropped out because
    of the Covid-19 outbreak. Of the participants who completed the study, 2 participants
    in the PLA-SUPP had been excluded because of poor compliance with wearing
    the knee brace through the immobilization section (S1 File).

    Additionally, myostatin inhibition prevented muscle weakness and muscle loss in mice with Huntington’s Disease, an inherited genetic dysfunction that causes muscle tissue to degenerate over time [17].

    In mice with continual kidney disease, inhibiting myostatin slowed the muscle loss brought on by kidney illness and enhanced
    the growth of forearm muscles [12]. In people, myostatin levels also
    usually increase with age, which can contribute to the loss of muscle mass during aging [6].
    Since there isn’t a lot formal analysis and long-term clinical trials are still pending, I would advise you consult your healthcare skilled before starting myostatin dietary supplements.

    In addition, ghrelin has been shown to prevent muscle atrophy in rats by enhancing AKT phosphorylation, suppressing the MSTN pathway,
    and activating myogenin and MyoD (Chen et al., 2015).

    Ghrelin formulations for parenteral administration are being developed (Garin et al., 2013).
    Nevertheless, administration by injection over extended intervals can lead to poor patient compliance
    and therapy failure, and ghrelin is vulnerable
    to enzymatic breakdown in blood when delivered intravenously (Brimijoin et al., 2016).

    Ghrelin liposomes coated with chitosan are being developed for nose-to-brain administration for the
    treatment of cachexia (Salade et al., 2017).
    This is important as a end result of previous a
    sure dimension, adding extra mass to muscle tissue doesn’t truly make them
    stronger – and muscular tissues which are too giant are also more vulnerable to damage.
    Over-developed muscle tissue can also get in the way of different necessary organs,
    reducing their measurement and impairing their functions [1, 2].
    PureRawz provides a high-quality peptide solution that’s
    perfect for those exploring the benefits
    of myostatin inhibitors.
    Additional work is warranted to establish the complete potential of blocking this
    essential pathway in musculoskeletal unloading and in spaceflight.
    Publicity of astronauts to reduced gravity throughout spaceflight disrupts homeostasis in musculoskeletal
    tissues leading to atrophy and lack of power. In each humans and rodents, skeletal muscle atrophy during spaceflight
    predominantly occurs in weight-bearing hindlimb muscle
    tissue including these answerable for plantar and dorsiflexion,
    knee and hip extension, and postural control1,2,three.

    References:

    new steroids on the market [anunciosclassificados.org]

    返信
  3. Maxwell より:
    2025年3月25日 10:37 AM

    This is all meant to create an arch in your chest, not your lower again.
    Keep your chest excessive, and shoulders collectively throughout the whole raise.
    You can also perform this exercise using a impartial or palms
    facing inward grip. The CGBP is unhealthy for you should you
    cannot do it safely with proper form. In general, if the CGBP is inflicting
    you any ache or discomfort, then you should cease doing it in its
    current kind and alter your strategy.
    If you have pain in your elbow joints while doing the shut grip bench, it is likely due to overuse harm.
    A longer distance to your chest means a longer time under rigidity
    and total just a weaker total performance with the amount of weight you can move.
    I wrote a complete article on how to bench press with
    lengthy arms, including some particular tips you could start to implement instantly.
    After that, we'll keep you up to date on the most important
    muscle-building research, lifting methods, and workout routines.
    On the other hand, the Shut Grip Bench Press requires your palms to be positioned nearer together, about shoulder width
    or narrower. Remember, the aim among athletes and health fanatics should
    at all times be most muscle improvement whereas minimizing injury threat.
    Skimping on the depth of your press limits the vary of motion and, consequently, the
    effectiveness of the exercise.
    The choice between the hex press and the shut grip bench press is determined by your individual fitness objectives and preferences.
    I even have never tried this, and dont have a bench to try it on, but wouldnt
    reverse grip bench presses be VERY dangerous?? Hell… just the visualization in my head of what
    a weak grip that may be would make me not strive it even if I had the capabilities to do so.

    Maintain your elbows in close to your physique during the entire movement, to avoid making them flare outwards.
    The flare of the elbows can add unnecessary stress to the shoulders and in addition work in opposition to the triceps contraction.
    Many individuals maintain their breath in the course of the hardest part of
    the motion causing inside physique strain. Inhale slowly as you decrease
    the bar to your chest, and exhale in the course of the
    push upward to start out position. If you’re new to weight lifting and this exercise, utilizing a spotter or smith machine is beneficial for security.
    Once you might be comfortable with the close-grip bench
    press and a spotter is unavailable, stay conservative with the weight masses continuing to work on good form and method.

    By specializing in the shut grip bench press, you might find that it targets the triceps extra effectively than the traditional bench press.
    This close grip variation requires a narrower hand
    spacing, which might result in elevated activation of the triceps muscles as seen in this study.

    The triceps brachii, situated on the again of the upper
    arm, take center stage during the shut grip bench press.

    The triceps' major perform is to lock out your arm, and the
    close grip bench press is the master at building your lockout
    in your bench press. The bench press would be the money maker for your chest, triceps,
    and shoulders as a compound exercise and pushing
    movement. But as we mentioned with the grip earlier, delicate modifications make a big distinction, even though it’s
    nonetheless just a bench press to the untrained eye. Performing
    the close-grip bench press promotes overall muscle steadiness as
    each muscle strength and gains are increased progressively and simultaneously.
    This can improve muscle perform and symmetry, another frequent goal for lifters.

    As Soon As you've mastered the basic close-grip bench press,
    listed under are some variations to maintain things fascinating...
    Perform the bench press to a board that's elevated off the
    chest. (Board height primarily based on training program,
    periodization, sticking point weaknesses, and athlete
    readiness). You’ll need a companion to carry the board in place whilst you bench.

    "Grip the bar so your hands are just barely exterior of the shoulders. If they're too shut together, the movement will feel clunky," says Reay.

    References:

    steroid drug

    返信
コメントを残す

エルデンリングまとめの関連記事
おすすめの記事