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152: 名無しさん 2022/05/28(土) 18:30:06.53
ソウルシリーズで初めて純米で始めてみたけど詠唱の段階で回避行動連発する敵多すぎて結局近接戦してるわ...
これみんなどうしてるの?今までもこんな感じだった?
156: 名無しさん 2022/05/28(土) 18:32:21.33
>>152
詠唱から発射までにラグのある魔術は直撃するゴミみたいなAIだぞ
今まではこんな露骨に入力反応して避けなかったはず
159: 名無しさん 2022/05/28(土) 18:33:03.76
>>152
魔術街サリアで夜の魔術に見えたまえよ
160: 名無しさん 2022/05/28(土) 18:33:08.19
>>152
純米てお酒か君は
真面目に返すと序盤は岩石弾、後半は夜の彗星とか避けられない魔術使えばいいよ
167: 名無しさん 2022/05/28(土) 18:36:53.54
>>156
マジかよ...賢くしようとして逆に馬鹿になってるのか?
>>159

>>160
とりあえずそいつら使ってみる!なんだかんだ今まで遠距離攻撃してなかったから楽しいわ

166: 名無しさん 2022/05/28(土) 18:36:26.66
>>152
まじゅちゅなら夜の彗星、岩石弾、渦巻くツブテ、輝剣辺りがモリモリ刺さるね
祈祷は残念ながら対策スペルがないから近接攻撃を適度に使わないといけないよ
遠距離戦を堪能したいなら知力一択だね
170: 名無しさん 2022/05/28(土) 18:39:08.16
>>152
輝剣とか岩石弾みたいな発生から発射まで時間かかる魔術とか、そもそも「回避されない」特性持ちの夜の魔術を使えばいい

ただ情報無しで進めると「糞回避野郎が!」って血管ブチギレて、武器で殴りかかる様になり、ラスボスまでそのまま武器で殴り倒して魔術糞ッ!ってなると思う

158: 名無しさん 2022/05/28(土) 18:32:35.56
いいお米で始めるな
163: 名無しさん 2022/05/28(土) 18:35:48.67
純米大吟醸!
164: 名無しさん 2022/05/28(土) 18:35:57.64
純魔の攻略最適解は両手喪失の夜の彗星だからな
まさか同じ杖2本持って攻略するはめになるとは思わんかった

引用元:https://pug.5ch.net/test/read.cgi/gamerpg/1653715121/

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    Introduction

    Types of Steroids

    Effects and Side Effects

    History and Usage

    # Contents

    ## Steroid
    Steroids are a class of organic compounds characterized by a specific
    type of chemical structure. They are primarily found in animals, plants, fungi, and some bacteria, where they play diverse roles in biological processes.
    Steroids have three interconnected rings, with functional groups
    such as hydroxyl or ketone groups attached to the molecule.
    Their structure is crucial for their activity, enabling them
    to act as hormones, vitamins, or other bioactive compounds.

    ## Page version status
    This page is based on content from Wikipedia and other reliable sources.
    It has been reviewed and updated by experts in the field.
    For more detailed information, please refer to the original
    source materials.

    ## Nomenclature
    The nomenclature of steroids refers to the systematic naming of these compounds.
    Steroids are named based on their structural features
    or biological functions. For example, "cholesterol" refers to
    a specific steroid molecule produced in the liver and
    used in animal cell membranes. Other examples include "sex hormones," such as estrogen and testosterone, which are steroidal molecules
    involved in reproduction and endocrine regulation.

    ## Rings and functional groups
    Steroids have a unique structure with three interconnected rings.
    The core of the steroid framework consists of two cyclohexane rings fused together, forming a bicyclic system.

    Functional groups, such as hydroxyl (-OH) or ketone (C=O) groups, are attached
    to this framework and play a critical role in determining the biological activity of
    the molecule. These functional groups can influence steroid behavior, such as their affinity for specific
    receptors or their solubility in different environments.

    ## Naming convention
    The naming convention for steroids follows specific rules that help differentiate between the various types of steroidal molecules.

    The name often includes a prefix derived from the class of compounds (e.g., "sterol" for cholesterol, "keto" for ketone-containing sterols).
    Additional suffixes may indicate modifications or functional groups present
    on the molecule. This system ensures clarity and precision in communication within scientific communities.

    ## Species distribution
    Steroids are distributed across a wide range of species. Their presence is not limited to one type of organism,
    as they can be found in both eukaryotes and prokaryotes.
    For example:
    - **Eukaryotic organisms**: Steroids are abundant in animals, plants, fungi,
    and single-celled eukaryotes like protozoa.
    - **Prokaryotic organisms**: Sterols, a type of steroid, are found in bacterial cell membranes and play a role in maintaining membrane integrity.

    ## Eukaryotic
    In eukaryotic organisms, steroids serve various biological
    functions. For instance:
    - Animals produce a wide variety of steroids, including sex hormones (e.g., estrogen, testosterone) that regulate reproduction and metabolism.

    - Plants synthesize sterols as part of their cell membranes, contributing to the strength and structure of
    these cellular structures.
    - Fungi also produce sterols, such as ergosterol, which is essential for the
    integrity of fungal cell membranes.

    ## Prokaryotic
    In prokaryotic organisms, sterols are a key component of bacterial cell membranes.
    These sterols help maintain membrane fluidity and flexibility, ensuring that the cell can function under various environmental conditions.
    While sterols are common in bacteria and archaea, they are not typically found in other types of prokaryotes,
    such as viruses.

    ## Fungal
    Fungi produce a variety of sterols, including ergosterol, which
    is a fundamental component of fungal cell membranes. Ergosterol's structure differs slightly from cholesterol,
    the primary sterol in animals, but it serves similar functions in maintaining membrane integrity and facilitating the
    transport of ions and nutrients across the membrane.

    ## Plant
    In plants, sterols are essential for the structural integrity of cellular
    membranes. Unlike animals, plants do not synthesize cholesterol but
    instead produce a related molecule called phytosterol. Phytosterols share some structural similarities with
    animal sterols but have unique features that make
    them suited to plant biology. These compounds contribute to membrane stability and help regulate growth and
    development in plants.

    ## Animal
    Animals are perhaps the most complex users of steroids, producing a
    vast array of these molecules for various purposes. For example:

    - **Sex hormones**: Steroids such as testosterone (male) and estrogen (female) play critical roles in reproduction and sexual differentiation.
    - **Adrenal steroids**: The adrenal glands produce corticosteroids, which are involved in stress response
    and immune function.
    - **Vitamin D**: A steroid molecule derived from cholesterol that is essential for bone health and calcium absorption.
    - **Other sterols**: Cholesterol itself is a vital component of animal cell
    membranes and precursor to various hormones and other bioactive compounds.

    ## Types
    Steroids can be categorized based on their function or structure:
    - **By function**: Sex steroids (e.g., estrogen, testosterone), adrenal steroids
    (e.g., cortisol), vitamin D derivatives, and sterols like cholesterol.

    - **By structure**: Intact ring systems, cleaved rings, contracted rings, or
    expanded rings.

    ## Rings and functional groups
    The number and arrangement of rings in the steroid framework influence its biological activity.
    For example:
    - **Intact ring system**: Steroids with all three rings intact often retain their
    basic structural features, allowing them to interact with specific
    receptors and perform normal cellular functions.

    - **Cleaved rings**: Modified steroids where
    one or more rings have been broken or altered can result in compounds with different properties.
    These derivatives may be more effective at targeting specific cellular
    pathways or receptors.
    - **Contracted rings**: Steroids with one ring contracted into a smaller, often five-membered structure are
    common in certain hormones and signaling molecules.
    - **Expanded rings**: Some steroid derivatives have additional carbons added to the ring system, altering their shape and function.

    ## Biological significance
    Steroids are biologically significant compounds with diverse roles in organisms.
    They serve as signaling molecules, hormone precursors, and structural components
    of cell membranes. For example:
    - **Signaling**: Steroids can act as hormones, transmitting signals within and between cells
    to regulate gene expression and cellular activity.
    - **Vitamin D**: A steroid derivative that is essential for bone health and
    calcium absorption.
    - **Cholesterol**: A major component of animal cell
    membranes, which also serves as a precursor for sex hormones and other steroidal molecules.

    ## Biosynthesis and metabolism
    The biosynthesis of steroids involves complex biochemical pathways
    that convert simple precursors into highly structured molecules.
    The two primary pathways for steroid synthesis
    are the Mevalonate pathway (also known as the cholesterol biosynthesis pathway) and the alternative pathways,
    such as the reverse transport of sterols in cells.

    ### Mevalonate pathway
    The Mevalonate pathway is a series of enzymatic reactions that
    convert acetyl-CoA into mevalonic acid, which serves as a precursor for the synthesis of cholesterol and other steroids.
    This pathway is active in most animals and plays a critical role in maintaining cellular health and homeostasis.

    ### Steroidogenesis
    Steroidogenesis refers to the process by which sterols are synthesized and
    modified into biologically active molecules. For example, cholesterol can be converted into vitamin D in sunlight, or transformed into sex hormones like estrogen and testosterone.
    This process is tightly regulated by the
    body to ensure that steroid levels remain within a healthy range.

    ### Alternative pathways
    In addition to the Mevalonate pathway, alternative pathways for steroid biosynthesis exist, particularly in certain tissues
    and organisms. These pathways may involve different precursors or unique enzymatic modifications, allowing for the production of specialized sterols tailored
    to specific biological needs.

    ### Catabolism and excretion
    Once steroids have fulfilled their biological function, they are broken down by enzymes known as steroid
    sulfatases and sulfotransferases. This process, known as
    catabolism, converts the steroids into inactive metabolites
    that can be safely excreted from the body.
    The excretion of sterols is a critical step in maintaining homeostasis and preventing the buildup of
    potentially harmful levels of these molecules.

    ## Isolation, structure determination, and methods of analysis
    The isolation and structural determination of steroids are essential for understanding their biological roles and
    developing new therapies. Techniques such as chromatography, mass spectrometry,
    and nuclear magnetic resonance (NMR) spectroscopy are
    commonly used to isolate and analyze steroidal compounds. These methods allow researchers to identify
    unknown steroids or study the structure of known molecules
    in detail.

    ## Chemical synthesis
    The chemical synthesis of steroids involves the use of organic chemistry techniques to construct these molecules from simpler precursors.
    While natural methods dominate in biological contexts, synthetic approaches have been developed for the purposes of research
    and drug development. Synthesis can be challenging due to
    the complexity of the steroid framework, but advanced methodologies have made it possible to
    create sterols with specific structural modifications.

    ### Precursors
    The synthesis of steroids begins with precursors such as mevalonic acid or isopentenyl pyrophosphate (IPP), which are derived
    from acetyl-CoA. These compounds undergo a series of enzymatic reactions to
    produce the steroid nucleus, the core structure of all sterols.

    ### Semisynthesis
    Semisynthesis involves the chemical manipulation of naturally
    occurring steroids or their derivatives to create new molecules with desired properties.
    This approach is particularly useful for modifying existing sterols to enhance their biological activity or improve their pharmacokinetics.

    ### Total synthesis
    Total synthesis refers to the de novo construction of steroids from non-steroidal
    precursors, without relying on natural sources. This method is often used in drug discovery to create molecules with therapeutic potential.
    The challenge lies in replicating the complex structure
    and biological activity of naturally occurring sterols.

    ## Research awards
    Over the years, significant research has been conducted
    into the chemistry, biology, and applications of steroids.
    Notable scientists in this field have received awards for their contributions to understanding steroid metabolism, biosynthesis, and function. These achievements have led to advancements in fields
    such as medicine, nutrition, and pharmacology.

    ## See also
    - **Lipid metabolism**
    - **Endocrinology**
    - **Biochemistry**

    ## References
    This article is based on publicly available information and does
    not constitute medical advice. Always consult a healthcare
    professional for medical concerns or before starting any new treatment
    regimen.

    my web site: steroids and libido [worldaid.eu.org]

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